Breakthrough in IPF Treatment as PureTech Announces Significant Phase 2b Trial Outcomes

Published: 01 May 2025
Clinical-stage biotherapeutics company, PureTech Health, is set to announce groundbreaking results from its Phase 2b ELEVATE IPF trial, showcasing the potential benefits of deupirfenidone for idiopathic pulmonary fibrosis patients.

In a pioneering move for the treatment of idiopathic pulmonary fibrosis (IPF), clinical-stage biotherapeutics company PureTech Health will soon announce the groundbreaking results from its Phase 2b ELEVATE IPF trial. Anticipated to take the medical world by storm, the trial data highlights the remarkable efficacy of deupirfenidone (LYT-100) for the treatment of this devastating disease.\

Set to be presented at the upcoming American Thoracic Society (ATS) International Conference, the trial findings have demonstrated the unprecedented potential of deupirfenidone to stabilise lung function decline over a 26-week period - a feat that current IPF therapies have yet to achieve. Chief Executive Officer of PureTech, Dr. Bharatt Chowrira, has emphasized the significance of this breakthrough, suggesting that deupirfenidone has the potential to set a new standard of care for IPF.\

The Phase 2b ELEVATE IPF trial, a global randomized double-blind study, involved 257 participants randomly receiving either deupirfenidone, pirfenidone or a placebo. The ability of deupirfenidone to stabilise lung function decline was evaluated against a baseline of pirfenidone and placebo.\

With PureTech ambitiously moving towards a Phase 3 trial, the company’s revolutionary approach to IPF treatment could bring about a transformative change in this field, providing much-needed hope to patients living with this fatal disease.