Revolutionary Obesity Drug from Novo Nordisk Yields Astounding Weight Loss Results in Recent Trials

Published: 21 Jun 2025
Impressive results have been revealed from Novo Nordisk's trials of a higher dosage of the pioneering obesity drug, Wegovy.

Trials of Novo Nordisk’s groundbreaking obesity medication, Wegovy, have culminated in compelling results, with a high dosage of the drug catalysing an average weight loss of 21% among participants. Notably, around one-third of those involved in the trial reported shedding a monumental 25% or more of their body mass, casting a hopeful light on the fight against obesity, a dire global health challenge. The STEP UP trial findings, presented at a scientific session of the American Diabetes Association, fortify existing evidence supporting the efficacy of Wegovy in fostering significant, and potentially life-altering, weight loss. The leader of the STEP UP study and medical director of the Wharton Medical Clinic, Sean Wharton, asserted that increasing the dosage of semaglutide (the active ingredient in Wegovy) resulted in even greater weight loss than previously observed. Furthermore, he suggested that these outstanding results could present an alternative method for those struggling to hit their weight targets. Clinical trials have also indicated the drug’s beneficial impact on patients with multiple co-morbid conditions such as heart diseases, type II diabetes, liver disease and knee osteoarthritis. The therapeutic impact of semaglutide in obesity management, indicated by these trials, is anticipated to increase the options for weight loss and overall health improvements for thousands of patients battling obesity. Novo Nordisk is optimistic about the pharmaceutical’s potential and is planning to apply for a label update in the EU in the latter half of 2025. With consistently robust and empirical evidence, the pharmaceutical company is aiming to expand the treatment’s availability in markets where Wegovy is already approved, offering a much-needed beacon of hope in the combat against obesity.